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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might bring about a rise in methadone plasma concentrations, which could induce potentially deadly respiratory melancholy. Also, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally lead to a rise i